Endocrine Abstracts

The aim: Of this study was to investigate the association between two common CTLA-4 gene SNPs (49A/G in exon 1 and CT60 A/G in 3’UTR) and Graves’ disease outcome in Lithuanian population.Methods: This case-control study was performed in the Hospital of Lithuanian University of Health Sciences. Graves’ disease patients (n=105) were divided into remission and failed treatment groups according to the final outcome of the disease. The...

Introduction: Papillary thyroid carcinoma (PTC) is the most common type of differentiated thyroid cancer of all cases of thyroid cancer. Fine-needle biopsy by ultrasonography is still the main diagnostic method of PTC, but there is a technical limitation. That’s why, a minimally invasive diagnostic test that can accurately diagnose the onset of the disease is the subject of research.Our objective: We aimed to explore the concentration levels of ...

Introduction: Papillary thyroid carcinoma (PTC) is the most common thyroid cancer type. It carries a good prognosis. However, approximately ten percent of cases may present with metastatic disease at initial presentation. Fine needle aspiration biopsy cytology is still the gold standard for diagnosing PTC, but there is a technical limitation. That’s why minimally invasive diagnostic test is the subject of research in nowadays.Our objective: We aimed...

Introduction: Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy. For the majority of patients with PTC, the prognosis is very good; however, up to 20% of patients suffer disease recurrence. Currently, the risk stratification for PTC recurrence is based on clinicopathological features which have limited prognostic value. Identification of molecular biomarkers of PTC recurrence such as protooncogene BRAF and miRNAs may help to improve risk-stratifie...

Introduction: Papillary thyroid carcinoma (PTC) is the most common type of differentiated thyroid cancer, accounting for about 80% of all cases of thyroid cancer. 20 – year survival rate is about 90%. However, PTC can be aggressive – up to 30% of the patients have local renewal or systemic spread.Our objective was to evaluated the clinicopathological factors of recurrence in completely resected PTC patients.Methods: A r...

Introduction: Lymphoma usually occurs within lymph nodes, but in rare cases, it arises from lymphocytes that are presented within the thyroid gland. Thyroid lymphoma is rare, representing less than 5% of thyroid malignancies and less than 2% of all lymphomas occurring outside of the lymph nodes and it is more likely to occur in people with Hashimoto’s thyroiditis. In this case we present a patient with Hashimoto’s thyroiditis (HT) and thyroid lymphom...

IntroductionIt has been observed that in patients with depression and anxiety disorders dopamine secretion is suppressed, therefore prolactin secretion increases. Prolonged hypercortisolemia causes a variety of psycho-emotional changes that may affect dopamine secretion.CaseA 36-year-old woman was admitted to the Hospital of Lithuanian University of Health Sciences Kauno Klinikos due to a 10-year-lasting gala...

Introduction: Papillary thyroid carcinoma (PTC) is the most common type of differentiated thyroid cancer, accounting for about 80% of all cases of thyroid cancer. Generally, PTC is an indolent disease and shows a good prognosis in most patients. However, up to 30% of patients have local tumor renewal or systemic spread. It is crucial to identify patients with a high risk of disease progression. DNA methylation biomarkers may provide clinically valuable information and improve ...

Introduction: Papillary thyroid cancer (PTC) is the most common type of thyroid cancer (85%–90%). Today Fine needle aspiration biopsy (FNAB) is the diagnostic tool for the evaluation of thyroid nodules because of its accuracy and cost-effectiveness, but FNAB also has limitations, as it is quite challenging to take a biopsy from a small thyroid nodule moreover FNAB diagnosis is doubtful in up to 20% of cases. Therefore, non-invasive biomarkers of PTC are needed.<p clas...

Introduction: Improper management of papillary thyroid carcinoma (PTC) patients results in potentially higher fatal outcomes due to a lack of relevant prognostic markers, inadequate periodic individualized risk assessments and/or insufficient initial treatment. MiR-146b, -21, -221, -222, -181b are potential biomarkers for risk stratification in PTC.Aim: The aim of our study was to analyze expression levels of five miRNA molecules (miR-21; miR -221; miR -...